Importance of cutaneous changes in the diagnosis of neurological diseases

DOI: 10.1590/S1679-45082014AI2931 A previous healthy 7-year-old boy presenting occipital headache and constantly wake up at night with 1 week of evolution was admitted to our emergency service. He had linear hypopigmented macules along the lines of Blaschko affecting hemithorax and left upper limbs (Figure 1). The patient also had macrocrania, antimongoloid palpebral fissure, changes in left eye pupil contour and syndactyly. A cranial computed tomography scan showed a hypodensity with accentuation of white Figure 1. Hypopigmented macules in the upper limb following the lines of Blaschko Figure 2. Coronal T2 weighted magnetic resonance (A) and axial fluid attenuated inversion recovery (FLAIR) (B). T2-weighted Hypersignal and FLAIR of white matter on brain hemispheres with periventricular and central predominance in almost symmetric and diffuse manner. Several cysts images spread throughout affected white matter (more linear configured at some areas), which seemed to correspond to dilatation of perivascular spaces A B